Gag Order
نویسندگان
چکیده
منابع مشابه
New insights into retroviral Gag–Gag and Gag–membrane interactions
A critical aspect of viral replication is the assembly of virus particles, which are subsequently released as progeny virus. While a great deal of attention has been focused on better understanding this phase of the viral life cycle, many aspects of the molecular details remain poorly understood. This is certainly true for retroviruses, including that of the human immunodeficiency virus type 1 ...
متن کاملDNA gag/adenovirus type 5 (Ad5) gag and Ad5 gag/Ad5 gag vaccines induce distinct T-cell response profiles.
Results from Merck's phase II adenovirus type 5 (Ad5) gag/pol/nef test-of-concept trial showed that the vaccine lacked efficacy against human immunodeficiency virus (HIV) infection in a high-risk population. Among the many questions to be explored following this outcome are whether (i) the Ad5 vaccine induced the quality of T-cell responses necessary for efficacy and (ii) the lack of efficacy i...
متن کاملRole of RNA in facilitating Gag/Gag-Pol interaction.
We have examined the influence of RNA upon the interaction of Gag-Pol with Gag during human immunodeficiency virus type 1 (HIV-1) assembly. COS7 cells were transfected with protease-negative HIV-1 proviral DNA, and Gag/Gag-Pol complexes were detected by coimmunoprecipitation with anti-integrase. In COS7 cells, Gag/Gag-Pol is found almost entirely in pelletable, membrane-bound complexes. Exposur...
متن کاملOperating under a Gag Order: a Block against Incoming Virus by the Fv1 Gene
Various MuLV isolates could be typed as either N-tropic (able to infect Fv1 mice), B-tropic (able to infect Fv1 The 1996 Cold Spring Harbor Retrovirus Meeting mice) or NB-tropic (able to infect cells of any genotype). opened with the triumphant and long-awaited report by The viral gene that determined the tropism of a virus Dr. Jonathan Stoye of the isolation of the Fv1 gene of was eventually i...
متن کاملHigher-Order Oligomerization Targets Plasma Membrane Proteins and HIV Gag to Exosomes
Exosomes are secreted organelles that have the same topology as the cell and bud outward (outward is defined as away from the cytoplasm) from endosome membranes or endosome-like domains of plasma membrane. Here we describe an exosomal protein-sorting pathway in Jurkat T cells that selects cargo proteins on the basis of both higher-order oligomerization (the oligomerization of oligomers) and pla...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2004
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2004.06.014